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  1. Article ; Online: Multimodale Therapiekonzepte lokaler Verfahren mit der Immuntherapie : Rationale für kombinatorische Ansätze und mögliche klinische Therapiestrategien.

    Eckert, Franziska

    Urologie (Heidelberg, Germany)

    2022  Volume 61, Issue 12, Page(s) 1324–1331

    Abstract: Immunotherapy has been established in the treatment of cancer in general and specifically in uro-oncology. The rationale to combine these therapies with radiotherapy is based on the biological effects of irradiation, which exceed the "physical" ... ...

    Title translation Multimodal treatment concepts of local radiation therapy with immunotherapy : Rationale for combination therapy and possible clinical treatment strategies.
    Abstract Immunotherapy has been established in the treatment of cancer in general and specifically in uro-oncology. The rationale to combine these therapies with radiotherapy is based on the biological effects of irradiation, which exceed the "physical" properties of irradiation to kill tumor cells. Depending on radiation dose and fractionation as well as tumor model or tumor entity used, irradiation can lead to immune stimulation or immune inhibition. As immune response is not limited to the local tumor microenvironment but occurs on a systemic level, a successful anticancer immune response after irradiation of one metastasis can lead to systemic tumor control (abscopal effect). Clinical trials test combination regimens in locally advanced tumors in the curative setting to improve survival rates and in the metastatic setting to prolong survival in palliative treatment. In addition, radiotherapy is used for local treatment of oligometastases and oligoprogression under palliative systemic therapy.
    MeSH term(s) Combined Modality Therapy
    Language German
    Publishing date 2022-11-22
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-7072
    ISSN (online) 2731-7072
    DOI 10.1007/s00120-022-01966-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Standing on the ramp: A young German radiation oncologist faces her ancestors.

    Eckert, Franziska

    Practical radiation oncology

    2017  Volume 7, Issue 5, Page(s) 293–294

    Language English
    Publishing date 2017-09
    Publishing country United States
    Document type Journal Article
    ISSN 1879-8519
    ISSN (online) 1879-8519
    DOI 10.1016/j.prro.2016.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Efficacy of a fish hydrolysate supplement on sleep quality: A randomized, double-blind, placebo-controlled, crossover clinical trial.

    Eckert, Franziska / Meyer, Nadin / Monzel, Elena / Bouvret, Elodie / Chataigner, Mathilde / Hellhammer, Juliane

    Clinical nutrition ESPEN

    2024  Volume 60, Page(s) 48–58

    Abstract: Background & aims: Sleep disturbances are widespread in modern societies and linked to a variety of diseases, creating an urgent need for the development of products that help combat sleep difficulties. One suitable nutritional supplement may be a fish ... ...

    Abstract Background & aims: Sleep disturbances are widespread in modern societies and linked to a variety of diseases, creating an urgent need for the development of products that help combat sleep difficulties. One suitable nutritional supplement may be a fish hydrolysate composed of low molecular weight peptides.
    Methods: This two-arm, double-blind, randomized, placebo-controlled crossover study investigated the effect of a 4-week fish hydrolysate intervention on sleep in a healthy German population reporting poor sleep quality, assessed with the Pittsburgh Sleep Quality Index (PSQI). Further sleep parameters were measured using an online diary and a wrist wearable device. Additionally, questionnaires related to stress, anxiety, depression, and well-being were evaluated and salivary cortisol and product satisfaction were assessed.
    Results: The 4-week fish hydrolysate supplementation significantly improved subjective sleep quality measured with the PSQI-score (p = .002). Moreover, individuals reported improvements in sleep efficacy and a reduction in sleep disturbances and daytime sleepiness during fish hydrolysate intake (p = .013, p = .046, p = .004 respectively), but not during placebo phase (all p > .05). No significant intra-individual differences were found between fish hydrolysate and placebo supplementation (p > .05).
    Conclusions: Although no significant intra-individual differences were found between fish hydrolysate and placebo supplementation, the significant improvement in subjective sleep quality from baseline to treatment phase suggests that fish hydrolysate is a safe nutritional supplement to support individuals with self-reported sleep problems.
    Clinical trial registration: The study is registered at ClinicalTrials.gov with the Identifier NCT04983355.
    MeSH term(s) Humans ; Sleep Quality ; Cross-Over Studies ; Treatment Outcome ; Sleep ; Sleep Initiation and Maintenance Disorders ; Dietary Supplements
    Language English
    Publishing date 2024-01-13
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2405-4577
    ISSN (online) 2405-4577
    DOI 10.1016/j.clnesp.2024.01.002
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  4. Article ; Online: Plasma sICAM-1 correlates with tumor volume before primary radiochemotherapy of head and neck squamous cell carcinoma patients

    Clasen Kerstin / Welz Stefan / Faltin Heidrun / Zips Daniel / Eckert Franziska

    Radiology and Oncology, Vol 56, Iss 4, Pp 501-

    2022  Volume 507

    Abstract: Biomarkers are of major interest to optimize diagnosis, prognosis and to guide treatment in head and neck cancer patients. Especially blood-based biomarkers appear promising as they can be easily collected and repeatedly analyzed during the course of ... ...

    Abstract Biomarkers are of major interest to optimize diagnosis, prognosis and to guide treatment in head and neck cancer patients. Especially blood-based biomarkers appear promising as they can be easily collected and repeatedly analyzed during the course of radiochemotherapy.
    Keywords head and neck cancer ; biomarker ; radiotherapy ; tumor volume ; gross tumor volume ; sicam-1 ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher Sciendo
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online ; Thesis: Retrospektive Analyse prognostischer Parameter für die lokale Kontrolle und das Überleben nach Bestrahlung stabilisierter Knochenmetastasen

    Wahl, Dominik Michael [Verfasser] / Eckert, Franziska [Akademischer Betreuer]

    2023  

    Author's details Dominik Michael Wahl ; Betreuer: Franziska Eckert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Tübingen
    Publishing place Tübingen
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  6. Article ; Online: Plasma sICAM-1 correlates with tumor volume before primary radiochemotherapy of head and neck squamous cell carcinoma patients.

    Clasen, Kerstin / Welz, Stefan / Faltin, Heidrun / Zips, Daniel / Eckert, Franziska

    Radiology and oncology

    2022  Volume 56, Issue 4, Page(s) 501–507

    Abstract: Background: Biomarkers are of major interest to optimize diagnosis, prognosis and to guide treatment in head and neck cancer patients. Especially blood-based biomarkers appear promising as they can be easily collected and repeatedly analyzed during the ... ...

    Abstract Background: Biomarkers are of major interest to optimize diagnosis, prognosis and to guide treatment in head and neck cancer patients. Especially blood-based biomarkers appear promising as they can be easily collected and repeatedly analyzed during the course of radiochemotherapy.
    Patients and methods: At first, for a broad overview, multiple immune markers were evaluated in six plasma samples of three head and neck squamous cell carcinoma (HNSCC) patients at the beginning and the end of radio-chemotherapy. In this pre-selection, the soluble Intercellular Adhesion Molecule 1 (sICAM-1) appeared most promising. Thus, this marker was measured in multiple samples (n = 86) during treatment and follow-up in a cohort of eleven patients and correlated with tumor features and clinical data.
    Results: We found a strong correlation between the initial levels of sICAM-1 in the plasma and the gross tumor volumes of the primary tumor and the involved lymph nodes. However, during the course of treatment no systematic dynamics could be identified. Toxicity or infections did not seem to influence sICAM-1 concentrations.
    Conclusions: sICAM-1 appears to reflect the pre-treatment total tumor burden (primary tumor and involved lymph nodes) in head and neck tumor patients. However, it does not seem to be a dynamic marker reflecting response during radiochemotherapy. Thus, if our findings are confirmed in future, sICAM-1 could be used as a staging marker: if high sICAM-1 levels but low tumor burden are found it might be reasonable to intensify staging investigations to rule out further, yet undetected, tumor sites.
    MeSH term(s) Humans ; Squamous Cell Carcinoma of Head and Neck/therapy ; Tumor Burden ; Intercellular Adhesion Molecule-1 ; Chemoradiotherapy ; Head and Neck Neoplasms/therapy
    Chemical Substances Intercellular Adhesion Molecule-1 (126547-89-5)
    Language English
    Publishing date 2022-12-13
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1128829-2
    ISSN 1581-3207 ; 0485-893X ; 1318-2099
    ISSN (online) 1581-3207
    ISSN 0485-893X ; 1318-2099
    DOI 10.2478/raon-2022-0043
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  7. Article: Ion channels as molecular targets of glioblastoma electrotherapy.

    Abed, Tayeb / Ganser, Katrin / Eckert, Franziska / Stransky, Nicolai / Huber, Stephan M

    Frontiers in cellular neuroscience

    2023  Volume 17, Page(s) 1133984

    Abstract: Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma. ...

    Abstract Therapies with weak, non-ionizing electromagnetic fields comprise FDA-approved treatments such as Tumor Treating Fields (TTFields) that are used for adjuvant therapy of glioblastoma.
    Language English
    Publishing date 2023-03-17
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2023.1133984
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  8. Article ; Online: DNA as the main target in radiotherapy-a historical overview from first isolation to anti-tumour immune response.

    Frey, Benjamin / Borgmann, Kerstin / Jost, Tina / Greve, Burkhard / Oertel, Michael / Micke, Oliver / Eckert, Franziska

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2023  Volume 199, Issue 12, Page(s) 1080–1090

    Abstract: DNA damage is one of the foremost mechanisms of irradiation at the biological level. After the first isolation of DNA by Friedrich Miescher in the 19th century, the structure of DNA was described by Watson and Crick. Several Nobel Prizes have been ... ...

    Abstract DNA damage is one of the foremost mechanisms of irradiation at the biological level. After the first isolation of DNA by Friedrich Miescher in the 19th century, the structure of DNA was described by Watson and Crick. Several Nobel Prizes have been awarded for DNA-related discoveries. This review aims to describe the historical perspective of DNA in radiation biology. Over the decades, DNA damage has been identified and quantified after irradiation. Depending on the type of sensing, different proteins are involved in sensing DNA damage and repairing the damage, if possible. For double-strand breaks, the main repair mechanisms are non-homologous end joining and homologous recombination. Additional mechanisms are the Fanconi anaemia pathway and base excision repair. Different methods have been developed for the detection of DNA double-strand breaks. Several drugs have been developed that interfere with different DNA repair mechanisms, e.g., PARP inhibitors. These drugs have been established in the standard treatment of different tumour entities and are being applied in several clinical trials in combination with radiotherapy. Over the past decades, it has become apparent that DNA damage mechanisms are also directly linked to the immune response in tumours. For example, cytosolic DNA fragments activate the innate immune system via the cGAS STING pathway.
    MeSH term(s) Humans ; DNA Repair ; Neoplasms/genetics ; Neoplasms/radiotherapy ; DNA Breaks, Double-Stranded ; DNA/radiation effects ; DNA End-Joining Repair ; DNA Damage
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2023-08-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-023-02122-5
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  9. Book: Langenscheidt Fachwörterbuch Kompakt Chemie Englisch

    Eckert, Franziska

    Englisch-Deutsch/Deutsch-Englisch = Langenscheidt dictionary of chemistry

    2012  

    Title variant Dictionary of chemistry ; Fachwörterbuch Kompakt Chemie Englisch ; Langenscheidt dictionary of chemistry
    Institution Technische Universität Dresden
    Author's details hrsg. von der Technischen Universität Dresden. [Bearb.: Franziska Krahl ...]
    Language English ; German
    Size 1007 S
    Edition 3., erw. Aufl
    Publisher Langenscheidt
    Publishing place Berlin u.a.
    Document type Book
    ISBN 3861173417 ; 9783861173410
    Database Former special subject collection: coastal and deep sea fishing

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  10. Article ; Online: Lokoregionale Tiefenhyperthermie verbessert das krankheitsspezifische Gesamtüberleben in Kombination mit einer neoadjuvanten Chemotherapie bei Hochrisiko-Weichteilsarkomen.

    Eckert, Franziska / Zips, Daniel

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2018  Volume 194, Issue 8, Page(s) 787–789

    Title translation Locoregional hyperthermia improves disease-specific overall survival in combination with neoadjuvant chemotherapy in high-risk soft tissue sarcomas.
    MeSH term(s) Adult ; Child ; Humans ; Hyperthermia, Induced ; Neoadjuvant Therapy ; Sarcoma ; Soft Tissue Neoplasms
    Language German
    Publishing date 2018-06-07
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-018-1322-2
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