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  1. Article ; Online: Confounded exposure metrics.

    Wiens, Matthew R / French, Jonathan L / Rogers, James A

    CPT: pharmacometrics & systems pharmacology

    2023  Volume 13, Issue 2, Page(s) 187–191

    Language English
    Publishing date 2023-11-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.13074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Welcome to the statistics and pharmacometrics themed issue.

    French, Jonathan / Mentré, France

    CPT: pharmacometrics & systems pharmacology

    2021  Volume 10, Issue 4, Page(s) 273–274

    MeSH term(s) Biological Variation, Population/drug effects ; Drug Development/methods ; Female ; Humans ; Male ; Models, Statistical ; Pharmaceutical Preparations/standards ; Pharmacokinetics ; Pharmacology, Clinical/organization & administration ; United States
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2021-05-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12625
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Use of Surgical Adhesive Tape to Maintain Tension on Intrafocal K-Wires for Easy Reduction and Fixation of Complex Intra-Articular Distal Radius Fractures.

    French, Jonathan M / Assiotis, Angelos / Uppal, Harpal S

    Cureus

    2021  Volume 13, Issue 1, Page(s) e12427

    Abstract: Maintaining reduction during fixation of complex intra-articular distal radius fractures with dorsal comminution can be challenging. We describe an operative technique where reduction is achieved with temporary intrafocal Kirschner wires (K-wires), and ... ...

    Abstract Maintaining reduction during fixation of complex intra-articular distal radius fractures with dorsal comminution can be challenging. We describe an operative technique where reduction is achieved with temporary intrafocal Kirschner wires (K-wires), and held using surgical adhesive tape wrapped around the hand, whilst a volar plate is applied to achieve rigid fixation. This is a simple, inexpensive method used at our institutions which allows fixation of these fractures without the need for an operative assistant.
    Language English
    Publishing date 2021-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.12427
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Pharmacometrics Golems: Exposure-Response Models in Oncology.

    Khandelwal, Akash / Grisic, Ana-Marija / French, Jonathan / Venkatakrishnan, Karthik

    Clinical pharmacology and therapeutics

    2022  Volume 112, Issue 5, Page(s) 941–945

    MeSH term(s) Humans ; Medical Oncology ; Models, Biological
    Language English
    Publishing date 2022-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 123793-7
    ISSN 1532-6535 ; 0009-9236
    ISSN (online) 1532-6535
    ISSN 0009-9236
    DOI 10.1002/cpt.2564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 20: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Variable or variate? A conundrum in pharmacometrics exposure-response models.

    Grisic, Ana-Marija / Venkatakrishnan, Karthik / French, Jonathan / Khandelwal, Akash

    CPT: pharmacometrics & systems pharmacology

    2022  Volume 12, Issue 2, Page(s) 144–147

    Abstract: Key elements of scientific writing-consistency and clarity-can be compromised in case of inaccurate use of methodological terms, especially in complex and multidisciplinary scientific fields. Such is the case in reports of pharmacometrics exposure- ... ...

    Abstract Key elements of scientific writing-consistency and clarity-can be compromised in case of inaccurate use of methodological terms, especially in complex and multidisciplinary scientific fields. Such is the case in reports of pharmacometrics exposure-response analyses with the use of the terms univariate/multivariate and univariable/multivariable. This perspective outlines the issues in the use of these terms, clarifies their definitions, provides examples, and makes recommendations for authors, reviewers, and journals in the fields of clinical pharmacology and pharmacometrics.
    MeSH term(s) Humans ; Pharmacology, Clinical ; Writing
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.12905
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bayesian estimation in NONMEM.

    Johnston, Curtis K / Waterhouse, Timothy / Wiens, Matthew / Mondick, John / French, Jonathan / Gillespie, William R

    CPT: pharmacometrics & systems pharmacology

    2023  Volume 13, Issue 2, Page(s) 192–207

    Abstract: Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic (PK) model ... ...

    Abstract Bayesian estimation is a powerful but underutilized tool for answering drug development questions. In this tutorial, the principles of Bayesian model development, assessment, and prior selection will be outlined. An example pharmacokinetic (PK) model will be used to demonstrate the implementation of Bayesian modeling using the nonlinear mixed-effects modeling software NONMEM.
    MeSH term(s) Humans ; Bayes Theorem ; Software ; Nonlinear Dynamics ; Models, Biological
    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2697010-7
    ISSN 2163-8306 ; 2163-8306
    ISSN (online) 2163-8306
    ISSN 2163-8306
    DOI 10.1002/psp4.13088
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Adverse reaction to metal debris due to fretting corrosion between the acetabular components of modular dual-mobility constructs in total hip replacement: a systematic review and meta-analysis.

    French, Jonathan M R / Bramley, Paul / Scattergood, Sean / Sandiford, Nemandra A

    EFORT open reviews

    2021  Volume 6, Issue 5, Page(s) 343–353

    Abstract: Modular dual-mobility (MDM) constructs can be used to reduce dislocation rates after total hip replacement (THR). However, there are concerns about adverse reaction to metal debris (ARMD) as a result of fretting corrosion between the metal liner and ... ...

    Abstract Modular dual-mobility (MDM) constructs can be used to reduce dislocation rates after total hip replacement (THR). However, there are concerns about adverse reaction to metal debris (ARMD) as a result of fretting corrosion between the metal liner and shell. This systematic review reports outcomes following THR using MDM components. It was registered with PROSPERO and conducted in line with Cochrane and PRISMA recommendations.Sixteen articles were included overall, with meta-analysis performed on relevant subsets using a random intercept logistic regression model. Estimated median incidence of ARMD requiring revision surgery within study follow-up period was 0.3% (95% CI 0.1 - 1.8%, from 11 cohort studies containing 1312 cases).Serum metal ion levels were mildly raised in 7.9% of cases, and significantly raised in 1.8%, but there was no correlation with worse clinical hip function scores within studies. Dislocation rate was 0.8%. Revision rate was 3.3%.There are mixed reports of wear on the backside of the metal liner from the acetabular shell and screw heads. Both implant design and component malseating are implicated, but currently it is unclear to what extent each factor is responsible.Studies were poor quality with high risk of confounding, especially from trunnion corrosion. We have made recommendations for further work. In the meantime, surgeons should be aware of the potential risk of ARMD when considering using an MDM prosthesis, and, if selecting one, must ensure proper seating of the liner and screws intraoperatively. Cite this article:
    Language English
    Publishing date 2021-05-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2844421-8
    ISSN 2058-5241 ; 2058-5241 ; 2396-7544
    ISSN (online) 2058-5241
    ISSN 2058-5241 ; 2396-7544
    DOI 10.1302/2058-5241.6.200146
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: International Survey of Practice for Prophylactic Systemic Antibiotic Therapy in Hip and Knee Arthroplasty.

    Parsons, Thomas / French, Jonathan / Oshima, Takeshi / Figueroa, Francisco / Neri, Thomas / Klasan, Antonio / Putnis, Sven

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 11

    Abstract: 1) Background: Prophylactic systemic antibiotics are acknowledged to be an important part of mitigating prosthetic joint infections. Controversy persists regarding optimal antibiotic regimes. We sought to evaluate current international antibiotics ... ...

    Abstract (1) Background: Prophylactic systemic antibiotics are acknowledged to be an important part of mitigating prosthetic joint infections. Controversy persists regarding optimal antibiotic regimes. We sought to evaluate current international antibiotics guidelines for total joint arthroplasty (TJA) of the hip and knee. (2) Methods: 42 arthroplasty societies across 6 continents were contacted and their published literature reviewed. (3) Results: 17 societies had guidelines; of which 11 recommended an antibiotic agent or antibiotic class (10-cephalosporin; 1-cloxacillin); 15 recommended antibiotic infusion within an hour of incision and 10 advised for post-operative doses (8-up to 24 h; 1-up to 36 h; 1-up to 48 h). (4) Conclusions: Prophylactic antibiotic guidelines for TJA are often absent or heterogenous in their advice.
    Language English
    Publishing date 2022-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11111669
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  9. Article: Virtual Trauma Meeting as a Component of Undergraduate Orthopaedic Education.

    Di Traglia, Rosalind / Rankin, Sally / French, Jonathan M / Ecott, Kathryn / Burnand, Henry / Monsell, Fergal

    Cureus

    2022  Volume 14, Issue 7, Page(s) e26810

    Abstract: Introduction: Virtual teaching has proven effective for medical students during the COVID-19 pandemic. This study is the first to describe an undergraduate orthopaedic teaching strategy in the format of virtual trauma meetings (VTM).: Methods: ... ...

    Abstract Introduction: Virtual teaching has proven effective for medical students during the COVID-19 pandemic. This study is the first to describe an undergraduate orthopaedic teaching strategy in the format of virtual trauma meetings (VTM).
    Methods: Clinical medical students from the Universities of Bristol and Cardiff were invited to attend five VTM between October and November 2020. These were delivered by consultants and speciality doctors via Zoom software. An 11-item feedback form was distributed after each session to assess the relevance of teaching material, student confidence in asking and answering questions, and if students would benefit from further sessions. Several open-ended questions were designed to evaluate aspects of the session that were most useful, which orthopaedic topics were of high priority and if they had any suggestions for improvement. Our initial aim was to assess student acceptance of the virtual format. Several months later pre-recorded material was uploaded onto YouTube and post hoc questionnaires were analysed.
    Results: A total of 50 students attended, with a median of 11±6 attending per session, producing a total of 26 feedback responses. Among the responders, there were 10 males and nine females and 63% of the students were in their third year. 100% of students felt comfortable asking questions and 96% felt comfortable answering questions. X-ray interpretation and management of fractures were the highest priority subjects. The majority of students considered the interaction between senior and junior doctors most valuable, and the most common improvement suggested was the inclusion of polls or OSCE-styled questions.
    Conclusions: VTM could be a useful resource to enhance undergraduate trauma and orthopaedic (T&O) education by providing student-focused material in an open learning environment.
    Language English
    Publishing date 2022-07-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.26810
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: A model-based analysis to guide gonadotropin-releasing hormone receptor antagonist use for management of endometriosis.

    Pohl, Oliver / Baron, Kyle / Riggs, Matthew / French, Jonathan / Garcia, Ramon / Gotteland, Jean-Pierre

    British journal of clinical pharmacology

    2022  Volume 88, Issue 5, Page(s) 2359–2371

    Abstract: Aims: To identify linzagolix doses, an oral GnRH receptor antagonist, that effectively lower oestradiol (E2) to relieve endometriosis-related pelvic pain without compromising bone health.: Methods: Integrated statistical, pharmacokinetic- ... ...

    Abstract Aims: To identify linzagolix doses, an oral GnRH receptor antagonist, that effectively lower oestradiol (E2) to relieve endometriosis-related pelvic pain without compromising bone health.
    Methods: Integrated statistical, pharmacokinetic-pharmacodynamic and systems pharmacology models were developed from Phase 1 and 2 clinical trial data in healthy volunteers and patients, receiving linzagolix 25-200 mg daily or placebo, and analysed simultaneously. The main outcome measures were pelvic pain scores for dysmenorrhoea, nonmenstrual pelvic pain (NMPP), uterine bleeding and lumbar spine bone mineral density (BMD).
    Results: Linzagolix pharmacokinetics were described by a 2-compartment model with sequential zero/first-order absorption process (CL/F: 0.422 L/h). E2 changes over time were well described as a function of linzagolix 24-hour AUC (AUC
    Discussion: The previously-reported E2 target range (20-50 pg/mL) to balance efficacy and safety endpoints was confirmed. Linzagolix once daily doses between 75-125 mg daily were expected to meet endometriosis-associated pain, efficacy, and BMD loss targets in Caucasian patients.
    MeSH term(s) Bone Density ; Carboxylic Acids ; Dysmenorrhea/drug therapy ; Endometriosis/drug therapy ; Female ; Hormone Antagonists/pharmacology ; Hormone Antagonists/therapeutic use ; Humans ; Pelvic Pain/drug therapy ; Pyrimidines ; Receptors, LHRH/therapeutic use
    Chemical Substances Carboxylic Acids ; Hormone Antagonists ; Pyrimidines ; Receptors, LHRH ; linzagolix (7CDW97HUEX)
    Language English
    Publishing date 2022-01-13
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 188974-6
    ISSN 1365-2125 ; 0306-5251 ; 0264-3774
    ISSN (online) 1365-2125
    ISSN 0306-5251 ; 0264-3774
    DOI 10.1111/bcp.15171
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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