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Article ; Online: Evaluation Model of Music Therapy's Auxiliary Effect on Mental Health Based on Artificial Intelligence Technology.

Lu, Dan

Journal of environmental and public health

2022 Volume 2022, Page(s) 9960589

Abstract: The reason why music can affect people's emotional experience is that the stimulation can be transmitted to the brain through hearing, such as the thalamus and lenticular nucleus. Music therapy has a positive auxiliary treatment effect on mental health. ... ...

Abstract	The reason why music can affect people's emotional experience is that the stimulation can be transmitted to the brain through hearing, such as the thalamus and lenticular nucleus. Music therapy has a positive auxiliary treatment effect on mental health. Therefore, an evaluation model of the auxiliary effect of music therapy on mental health based on artificial intelligence technology is proposed. We construct the constraint index parameters for the evaluation of music therapy's auxiliary effect on mental health, take parent pressure, self-pressure, teacher pressure, and social pressure as the questionnaire object parameters, take class type as the independent variable, carry out an independent sample
MeSH term(s)	Artificial Intelligence ; Humans ; Mental Health ; Music/psychology ; Music Therapy/methods ; Reproducibility of Results ; Technology
Language	English
Publishing date	2022-09-23
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2526611-1
ISSN	1687-9813 ; 1687-9813
ISSN (online)	1687-9813
ISSN	1687-9813
DOI	10.1155/2022/9960589
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Students' Perceptions of a Blended Learning Environment to Promote Critical Thinking.

Lu, Dan

Frontiers in psychology

2021 Volume 12, Page(s) 696845

Abstract: Critical thinking is considered as one of the indispensable skills that must be possessed by the citizens of modern society, and its cultivation with blended learning has drawn much attention from researchers and practitioners. This study proposed the ... ...

Abstract	Critical thinking is considered as one of the indispensable skills that must be possessed by the citizens of modern society, and its cultivation with blended learning has drawn much attention from researchers and practitioners. This study proposed the construction of a blended learning environment, where the pedagogical, social, and technical design was directed to fostering critical thinking. The purpose of the study was to find out students' perceptions of the learning environment concerning its design and its influence on their critical thinking. Adopting the mixed method, the study used questionnaire and interview as the instruments for data collection. The analysis of the data revealed that the students generally held positive perceptions of the environment, and they believed that the blended learning environment could help promote their critical thinking in different aspects.
Language	English
Publishing date	2021-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.696845
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Article ; Online: MicroRNA-223-3p downregulates the inflammatory response in preeclampsia placenta via targeting NLRP3.

Liu, Xueqiong / Li, Zhiyue / Lu, Dan

BMC pregnancy and childbirth

2024 Volume 24, Issue 1, Page(s) 175

Abstract: Objective: To investigate the regulatory role of miR-223-3p in the inflammatory response of PE placenta.: Methods: PE and normal placental tissues were collected to measure the expression of NLRP3 and miR-223-3p. The targeting relationship between ... ...

Abstract	Objective: To investigate the regulatory role of miR-223-3p in the inflammatory response of PE placenta. Methods: PE and normal placental tissues were collected to measure the expression of NLRP3 and miR-223-3p. The targeting relationship between NLRP3 and miR-223-3P was verified by bioinformatics analysis and classical double-luciferase reporter gene assay. Lipopolysaccharide (LPS) was used to induce HTR8/SVneo cells as PE placental cell inflammation model. Then we transfected miR-223-3p overexpression/miR-223-3p negative control plasmid into the LPS-induced HTR8/SVneo cells. Next, the expressions of NLRP3, Caspase-1, GSDMD, IL-1β and IL-18 were evaluated to elucidate the regulatory effect of miR-223-3p on the inflammatory response mediated by NLRP3 in PE placenta. Results: Compared with normal controls, NLRP3 was significantly up-regulated in PE placenta, while miR-223-3p was down-regulated. In addition, NLRP3 was a direct target of miR-223-3p. Further research revealed that the expression of NLRP3, Caspase-1, GSDMD, IL-1β and IL-18 could be obviously promoted in HTR8/SVneo cells treated with LPS (500 ng/ml) for 24 h, nevertheless it could be significantly suppressesed under the overexpression of miR-223-3p. Conclusion: MiR-223-3p suppressed NLRP3 inflamariomes activation, downstream inflammatory factors secretion and pyroptosis in LPS-induced HTR8/SVneo cells indicating that miR-223-3p could serve as an anti-inflammatory factor in preeclampsia.
MeSH term(s)	Female ; Humans ; Pregnancy ; Caspases ; Interleukin-18 ; Lipopolysaccharides/pharmacology ; MicroRNAs/genetics ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Placenta ; Pre-Eclampsia/genetics
Chemical Substances	Caspases (EC 3.4.22.-) ; Interleukin-18 ; Lipopolysaccharides ; MicroRNAs ; MIRN223 microRNA, human ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human
Language	English
Publishing date	2024-03-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2059869-5
ISSN	1471-2393 ; 1471-2393
ISSN (online)	1471-2393
ISSN	1471-2393
DOI	10.1186/s12884-024-06371-9
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Article: Emotional Contagion: Research on the Influencing Factors of Social Media Users' Negative Emotional Communication During the COVID-19 Pandemic.

Lu, Dan / Hong, Dian

Frontiers in psychology

2022 Volume 13, Page(s) 931835

Abstract: During the epidemic, social media platforms were frequently used by users to express and spread negative emotions. Under emotional contagion, individual emotions gradually generalized into group emotions. At the same time, the public could not regulate ... ...

Abstract	During the epidemic, social media platforms were frequently used by users to express and spread negative emotions. Under emotional contagion, individual emotions gradually generalized into group emotions. At the same time, the public could not regulate their emotions and lacked access to release them rationally. This study explores the factors influencing the negative emotions' communication among social media users during the COVID-19 epidemic from the perspective of emotion contagion theory to discover the psychological mechanisms among the public. The questionnaire was tested for reliability and validity and then distributed online on Chinese social media platforms, and the data collected were statistically analyzed. The findings show that there are significant differences in negative emotional communication in social media among different age groups; the seven dimensions of deindividuation, risk perception, group identity, group efficacy, event stimulation, event publicness, and emotion contagion all have significant positive effects on users' negative emotional communication. This study aims to raise public awareness of negative emotions and promote the reconstruction and recovery of public mental health in the epidemic era.
Language	English
Publishing date	2022-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.931835
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Article ; Online: Performance of Cox proportional hazard models on recovering the ground truth of confounded exposure-response relationships for large-molecule oncology drugs.

Poon, Victor / Lu, Dan

CPT: pharmacometrics & systems pharmacology

2022 Volume 11, Issue 11, Page(s) 1511–1526

Abstract: A Cox proportional hazard (CoxPH) model is conventionally used to assess exposure-response (E-R), but its performance to uncover the ground truth when only one dose level of data is available has not been systematically evaluated. We established a ... ...

Abstract	A Cox proportional hazard (CoxPH) model is conventionally used to assess exposure-response (E-R), but its performance to uncover the ground truth when only one dose level of data is available has not been systematically evaluated. We established a simulation workflow to generate realistic E-R datasets to assess the performance of the CoxPH model in recovering the E-R ground truth in various scenarios, considering two potential reasons for the confounded E-R relationship. We found that at high doses, when the pharmacological effects are largely saturated, missing important confounders is the major reason for inferring false-positive E-R relationships. At low doses, when a positive E-R slope is the ground truth, either missing important confounders or mis-specifying the interactions can lead to inaccurate estimates of the E-R slope. This work constructed a simulation workflow generally applicable to clinical datasets to generate clinically relevant simulations and provide an in-depth interpretation on the E-R relationships with confounders inferred by the conventional CoxPH model.
MeSH term(s)	Humans ; Proportional Hazards Models ; Computer Simulation
Language	English
Publishing date	2022-09-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2697010-7
ISSN	2163-8306 ; 2163-8306
ISSN (online)	2163-8306
ISSN	2163-8306
DOI	10.1002/psp4.12859
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Article ; Online: Letter by Lu et al. regarding article, "Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia".

Deng, Zhuo / Lu, Dan

Hypertension in pregnancy

2022 Volume 41, Issue 1, Page(s) 51–52

MeSH term(s)	Esomeprazole ; Female ; Humans ; Placenta ; Pre-Eclampsia/drug therapy ; Pregnancy ; Sulfasalazine/pharmacology ; Sulfasalazine/therapeutic use ; Vascular Endothelial Growth Factor Receptor-1
Chemical Substances	Sulfasalazine (3XC8GUZ6CB) ; Vascular Endothelial Growth Factor Receptor-1 (EC 2.7.10.1) ; Esomeprazole (N3PA6559FT)
Language	English
Publishing date	2022-01-02
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	1151886-8
ISSN	1525-6065 ; 1064-1955
ISSN (online)	1525-6065
ISSN	1064-1955
DOI	10.1080/10641955.2021.2024224
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Article ; Online: Regarding 'Gestational age at initiation of 17-alpha hydroxyprogesterone caproate and recurrent preterm birth'.

Deng, Zhuo / Lu, Dan

European journal of obstetrics, gynecology, and reproductive biology

2022 Volume 270, Page(s) 246

MeSH term(s)	17 alpha-Hydroxyprogesterone Caproate ; Gestational Age ; Humans ; Hydroxyprogesterones/therapeutic use ; Infant, Newborn ; Premature Birth/prevention & control ; Progestins/therapeutic use
Chemical Substances	Hydroxyprogesterones ; Progestins ; 17 alpha-Hydroxyprogesterone Caproate (276F2O42F5)
Language	English
Publishing date	2022-02-08
Publishing country	Ireland
Document type	Letter ; Comment
ZDB-ID	190605-7
ISSN	1872-7654 ; 0301-2115 ; 0028-2243
ISSN (online)	1872-7654
ISSN	0301-2115 ; 0028-2243
DOI	10.1016/j.ejogrb.2022.02.004
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Article ; Online: The optimal exercise intervention for sleep quality in adults: A systematic review and network meta-analysis.

Xie, Wenjie / Lu, Dan / Liu, Siyou / Li, Junping / Li, Rui

Preventive medicine

2024 Volume 183, Page(s) 107955

Abstract: Background: The impact of various exercise modalities on the improvement of sleep quality in adults remains controversial.: Objective: This study aimed to perform a network meta-analysis to analyze the effects of different exercise interventions on ... ...

Abstract	Background: The impact of various exercise modalities on the improvement of sleep quality in adults remains controversial. Objective: This study aimed to perform a network meta-analysis to analyze the effects of different exercise interventions on sleep quality in adults. Methods: The PubMed, Cochrane, Embase, Web of Science, and EBSCO databases were searched for studies published from March 18, 1993, to March 18, 2023. The Cochrane risk of bias tool was used to assess the quality of the included studies. Then, a random-effects network meta-analysis was conducted within a frequentist framework. Results: A total of 2142 participants from 27 randomized controlled trials were included in the analysis. Exercise modalities such as Pilates, yoga, and traditional Chinese exercises were found to significantly improve sleep quality when compared to a no-exercise control group, with Pilates exhibiting the most potent effect at a 95.3% improvement level. Conclusion: This study demonstrates that exercise interventions are effective in enhancing sleep quality in adults. Adapting exercise to individual preferences and needs may maximize the sleep-related benefits of the activity. Registration: The review was registered with PROSPERO, registration number CRD42023434565.
Language	English
Publishing date	2024-04-18
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	184600-0
ISSN	1096-0260 ; 0091-7435
ISSN (online)	1096-0260
ISSN	0091-7435
DOI	10.1016/j.ypmed.2024.107955
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Article ; Online: Severity of COVID-19 infection in patients with COVID-19 combined with diabetes.

Lu, Dan / Liu, Yuhong / Ma, Pengcheng / Hou, Rui / Wang, Jin

Journal of health, population, and nutrition

2024 Volume 43, Issue 1, Page(s) 55

Abstract: Purpose: This study aimed to analyse the correlation between blood glucose control and the severity of COVID-19 infection in patients with diabetes.: Methods: Clinical and imaging data of a total of 146 patients with diabetes combined with COVID-19 ... ...

Abstract	Purpose: This study aimed to analyse the correlation between blood glucose control and the severity of COVID-19 infection in patients with diabetes. Methods: Clinical and imaging data of a total of 146 patients with diabetes combined with COVID-19 who visited our hospital between December 2022 and January 2023 were retrospectively collected. The patients were divided into the 'good blood glucose control' group and the 'poor blood glucose control' group based on an assessment of their blood glucose control. The clinical data, computed tomography (CT) appearance and score and the severity of COVID-19 infection of the two groups were compared, with the severity of COVID-19 infection being the dependent variable to analyse other influencing factors. Results: The group with poor blood glucose control showed a higher lobar involvement degree and total CT severity score (CTSS) than the group with good blood glucose control (13.30 ± 5.25 vs. 10.38 ± 4.84, p < 0.05). The two groups exhibited no statistically significant differences in blood lymphocyte, leukocyte, C-reaction protein, pleural effusion, consolidation, ground glass opacity or crazy-paving signs. Logistic regression analysis showed that the total CTSS significantly influences the clinical severity of patients (odds ratio 1.585, p < 0.05), whereas fasting plasma glucose and blood glucose control are not independent factors influencing clinical severity (both p > 0.05). The area under the curve (AUC) of CTSS prediction of critical COVID-19 was 0.895 with sensitivity of 79.3% and specificity of 88.1% when the threshold value is 12. Conclusion: Blood glucose control is significantly correlated with the CTSS; the higher the blood glucose is, the more severe the lung manifestation. The CTSS can also be used to evaluate and predict the clinical severity of COVID-19.
MeSH term(s)	Humans ; COVID-19/complications ; COVID-19/blood ; Male ; Female ; Severity of Illness Index ; Middle Aged ; Retrospective Studies ; Blood Glucose/analysis ; Tomography, X-Ray Computed ; Aged ; Diabetes Mellitus/blood ; SARS-CoV-2 ; Adult
Chemical Substances	Blood Glucose
Language	English
Publishing date	2024-04-23
Publishing country	Bangladesh
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2025045-9
ISSN	2072-1315 ; 1606-0997
ISSN (online)	2072-1315
ISSN	1606-0997
DOI	10.1186/s41043-024-00548-w
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Article: A Case of Sotos Syndrome in a Preterm Infant with Severe Bronchopulmonary Dysplasia and Congenital Heart Disease.

Lu, Dan-Fang / Tong, Xiao-Mei / Liu, Yun-Feng

Children (Basel, Switzerland)

2023 Volume 10, Issue 7

Abstract: Sotos syndrome is an autosomal dominant genetic disorder caused by mutations in the NSD1 gene. In this study, we report a case of Sotos syndrome in a preterm infant. The main clinical manifestations were severe bronchopulmonary dysplasia, congenital ... ...

Abstract	Sotos syndrome is an autosomal dominant genetic disorder caused by mutations in the NSD1 gene. In this study, we report a case of Sotos syndrome in a preterm infant. The main clinical manifestations were severe bronchopulmonary dysplasia, congenital heart disease, difficulty feeding, and characteristic facial appearance. The gene mutation was located at 177251854 on chromosome 5, and identified as a shear mutation, c.4765+1 G > A, which is a new mutation. The patient recovered well after symptomatic treatment. To the best of our knowledge, this is the first case of a preterm infant in whom a novel c.4765+1 G > A mutation in the NSD1 gene was identified. When premature infants present with abnormally severe bronchopulmonary dysplasia, feeding difficulties, and other congenital anomalies, Sotos syndrome should be considered.
Language	English
Publishing date	2023-06-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2732685-8
ISSN	2227-9067
ISSN	2227-9067
DOI	10.3390/children10071111
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