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  1. Artikel ; Online: Are serious games seriously good at preparing students for clinical practice?: A randomized controlled trial.

    Perron, Janaya Elizabeth / Uther, Penelope / Coffey, Michael Jonathon / Lovell-Simons, Andrew / Bartlett, Adam W / McKay, Ashlene / Garg, Millie / Lucas, Sarah / Cichero, Jane / Dobrescu, Isabella / Motta, Alberto / Taylor, Silas / Kennedy, Sean Edward / Ooi, Chee Yee

    Medical teacher

    2024  , Seite(n) 1–8

    Abstract: Purpose: Serious games (SGs) have great potential for pediatric medical education. This study evaluated the efficacy of a SG in improving learner satisfaction, knowledge, and behavior.: Materials and methods: This was an investigator-blinded ... ...

    Abstract Purpose: Serious games (SGs) have great potential for pediatric medical education. This study evaluated the efficacy of a SG in improving learner satisfaction, knowledge, and behavior.
    Materials and methods: This was an investigator-blinded randomized controlled trial (RCT) comparing a SG against two controls: (i) adaptive tutorial (AT), and (ii) low-stimulus control (LSC). SG is a highly immersive role-playing game in a virtual hospital. AT delivers interactive web-based lessons. LSC is paper-based clinical practice guidelines. Metropolitan senior medical students at UNSW were eligible. A total of 154 enrolled and were block randomized to one intervention. Participants had access to one intervention for 8 weeks which taught pediatric acute asthma and seizure assessment and management. Satisfaction was assessed with Likert-scale responses to 5 statements and 2 free-text comments. Knowledge was assessed with 10 multiple-choice questions (MCQs). Clinical behavior was assessed during a 30-point simulated clinical management scenario (CMS). Primary analysis was performed on a modified intention-to-treat basis and compared: (1) SG
    Results: A total of 118 participants were included in the primary analysis (modified intention-to-treat model). No significant differences in MCQ results between the SG and control groups. SG group outperformed the LSC group in the CMS, with a moderate effect (score out of 30: 20.8 (3.2)
    Conclusions: This is the first investigator-blinded RCT assessing the efficacy of a highly immersive SG on learner attitudes, knowledge acquisition, and performance in simulated pediatric clinical scenarios. The SG demonstrated improved translation of knowledge to a simulated clinical environment, particularly compared to LSC. SGs show promise in pediatric medical education.
    Sprache Englisch
    Erscheinungsdatum 2024-03-09
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 424426-6
    ISSN 1466-187X ; 0142-159X
    ISSN (online) 1466-187X
    ISSN 0142-159X
    DOI 10.1080/0142159X.2024.2323179
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Resolution of Intestinal Histopathology Changes in Cystic Fibrosis after Treatment with Ivacaftor.

    Safe, Mark / Gifford, Andrew J / Jaffe, Adam / Ooi, Chee Yee

    Annals of the American Thoracic Society

    2016  Band 13, Heft 2, Seite(n) 297–298

    Mesh-Begriff(e) Aminophenols/therapeutic use ; Child ; Cystic Fibrosis/drug therapy ; Cystic Fibrosis/pathology ; Duodenum/pathology ; Humans ; Mucus ; Quinolones/therapeutic use ; Treatment Outcome
    Chemische Substanzen Aminophenols ; Quinolones ; ivacaftor (1Y740ILL1Z)
    Sprache Englisch
    Erscheinungsdatum 2016-02
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Letter
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201510-669LE
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Evaluating the Dietary Intakes of Energy, Macronutrients, Sugar, Fiber, and Micronutrients in Children With Celiac Disease.

    Ting, Alison / Katz, Tamarah / Sutherland, Rosie / Liu, Victoria / Tong, Chai Wei / Gao, Yajuan / Lemberg, Daniel A / Krishnan, Usha / Gupta, Nitin / Coffey, Michael J / Ooi, Chee Yee

    Journal of pediatric gastroenterology and nutrition

    2020  Band 71, Heft 2, Seite(n) 246–251

    Abstract: Objectives: Children with celiac disease (CD) follow a lifelong gluten-free diet. This restrictive diet may be associated with nutritional compromise. Our objectives were, therefore, to evaluate the dietary composition (energy, macronutrients and ... ...

    Abstract Objectives: Children with celiac disease (CD) follow a lifelong gluten-free diet. This restrictive diet may be associated with nutritional compromise. Our objectives were, therefore, to evaluate the dietary composition (energy, macronutrients and micronutrients, and fiber) in children with CD compared with healthy controls (HC) and relationship between dietary composition and socioeconomic status.
    Methods: This cross-sectional, case-control study recruited children with CD ages 2 to 18 years and HC matched for age, sex, and socioeconomic status. Clinical, sociodemographic, and dietary information were collected. A false discovery rate correction was applied to the P-value for multiple comparisons (q-value).
    Results: Sixty-five CD children were matched with 65 HC (mean [SD] age: 10.2 [3.6] vs 10.1 [3.7] years, P = 0.96). Compared with HC, CD children had higher intakes of energy (2413.2 [489.9] vs 2190.8 (593.5) kcal/day, P = 0.02), total fat (818.1 ± 180.9 vs 714.3 ± 212.2 kcal/day, q = 0.018), and subtypes of fat (saturated, polyunsaturated, and monounsaturated). There were no differences in other macronutrients, sugar, micronutrients, or fiber between CD and HC, and no difference in dietary intake among CD between socioeconomic disadvantage versus advantage. Children with CD had lower weight z-scores (-0.06 [1.05] vs 0.47 [0.96], P = 0.003) and body mass index (BMI) z-scores (-0.02 [0.88] vs 0.41 [1.09], P = 0.02) than HC.
    Conclusions: Children with CD had higher calorie and fat intake compared with HC. Despite this, CD children had lower weight and BMI z-scores compared with HC.
    Mesh-Begriff(e) Adolescent ; Body Mass Index ; Case-Control Studies ; Celiac Disease ; Child ; Child, Preschool ; Cross-Sectional Studies ; Diet ; Dietary Fats ; Dietary Fiber ; Eating ; Energy Intake ; Humans ; Micronutrients ; Sugars
    Chemische Substanzen Dietary Fats ; Dietary Fiber ; Micronutrients ; Sugars
    Sprache Englisch
    Erscheinungsdatum 2020-05-08
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000002743
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel: Probiotics in paediatric gastrointestinal diseases.

    Lemberg, Daniel A / Ooi, Chee Yee / Day, Andrew S

    Journal of paediatrics and child health

    2007  Band 43, Heft 5, Seite(n) 331–336

    Abstract: Probiotics have become increasingly popular and are now promoted as having a wide range of benefits. Probiotics are generally very well tolerated and safe but many of the purported uses are not yet well supported with adequate scientific evidence. Two ... ...

    Abstract Probiotics have become increasingly popular and are now promoted as having a wide range of benefits. Probiotics are generally very well tolerated and safe but many of the purported uses are not yet well supported with adequate scientific evidence. Two well-established roles for probiotics in children are acute diarrhoeal illness and antibiotic-associated diarrhoea. This review summarises the evidence supporting probiotics for various gastrointestinal disorders with particular reference to their role in the management of acute diarrhoea and antibiotic-associated diarrhoea in children.
    Mesh-Begriff(e) Child ; Child, Preschool ; Gastrointestinal Diseases/drug therapy ; Humans ; Infant ; Probiotics/therapeutic use
    Sprache Englisch
    Erscheinungsdatum 2007-05
    Erscheinungsland Australia
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1024476-1
    ISSN 1440-1754 ; 1034-4810
    ISSN (online) 1440-1754
    ISSN 1034-4810
    DOI 10.1111/j.1440-1754.2007.01076.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 227: Hefte anzeigen Standort:
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  5. Artikel ; Online: Diabetes Mellitus in Children with Acute Recurrent and Chronic Pancreatitis: Data From the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE Cohort.

    Bellin, Melena D / Lowe, Mark / Zimmerman, M Bridget / Wilschanski, Michael / Werlin, Steven / Troendle, David M / Shah, Uzma / Schwarzenberg, Sarah J / Pohl, John F / Perito, Emily / Ooi, Chee Yee / Nathan, Jaimie D / Morinville, Veronique D / McFerron, Brian A / Mascarenhas, Maria R / Maqbool, Asim / Liu, Quin / Lin, Tom K / Husain, Sohail Z /
    Himes, Ryan / Heyman, Melvin B / Gonska, Tanja / Giefer, Matthew J / Gariepy, Cheryl E / Freedman, Steven D / Fishman, Douglas S / Barth, Bradley / Abu-El-Haija, Maisam / Uc, Aliye

    Journal of pediatric gastroenterology and nutrition

    2019  Band 69, Heft 5, Seite(n) 599–606

    Abstract: Objectives: Adults with chronic pancreatitis (CP) have a high risk for developing pancreatogenic diabetes mellitus (DM), but little is known regarding potential risk factors for DM in children with acute recurrent pancreatitis (ARP) or CP. We compared ... ...

    Abstract Objectives: Adults with chronic pancreatitis (CP) have a high risk for developing pancreatogenic diabetes mellitus (DM), but little is known regarding potential risk factors for DM in children with acute recurrent pancreatitis (ARP) or CP. We compared demographic and clinical features of children with ARP or CP, with and without DM, in the INternational Study Group of Pediatric Pancreatitis: In Search for a CuRE (INSPPIRE) registry.
    Methods: We reviewed the INSPPIRE database for the presence or absence of physician-diagnosed DM in 397 children, excluding those with total pancreatectomy with islet autotransplantation, enrolled from August 2012 to August 2017. Patient demographics, BMI percentile, age at disease onset, disease risk factors, disease burden, and treatments were compared between children with DM (n = 24) and without DM (n = 373).
    Results: Twenty-four children (6% of the cohort) had a diagnosis of DM. Five of 13 tested were positive for beta cell autoantibodies. The DM group was 4.2 years [95% confidence interval (CI) 3-5.4] older at first episode of acute pancreatitis, and tended to more often have hypertriglyceridemia [odds ratio (OR) 5.21 (1.33-17.05)], coexisting autoimmune disease [OR 3.94 (0.88-13.65)] or pancreatic atrophy [OR 3.64 (1.13, 11.59)].
    Conclusion: Pancreatic atrophy may be more common among children with DM, suggesting more advanced exocrine disease. However, data in this exploratory cohort also suggest increased autoimmunity and hypertriglyceridemia in children with DM, suggesting that risk factors for type 1 and type 2 DM, respectively may play a role in mediating DM development in children with pancreatitis.
    Mesh-Begriff(e) Acute Disease ; Adolescent ; Child ; Cohort Studies ; Databases, Factual ; Diabetes Mellitus, Type 2/blood ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Female ; Global Health ; Humans ; Male ; Pancreatitis/complications ; Pancreatitis, Chronic/complications ; Prevalence ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2019-10-22
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 603201-1
    ISSN 1536-4801 ; 0277-2116
    ISSN (online) 1536-4801
    ISSN 0277-2116
    DOI 10.1097/MPG.0000000000002482
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Thrombotic events after pediatric liver transplantation.

    Ooi, Chee Yee / Brandão, Leonardo R / Zolpys, Lauren / De Angelis, Maria / Drew, Wendy / Jones, Nicola / Ling, Simon C / Fecteau, Annie / Ng, Vicky Lee

    Pediatric transplantation

    2010  Band 14, Heft 4, Seite(n) 476–482

    Abstract: TE may contribute to morbidity and mortality after LT. The objectives were to determine the incidence of early TE post-pediatric LT and compare differences between children with and without TE. A retrospective review of 88 transplanted children (January ... ...

    Abstract TE may contribute to morbidity and mortality after LT. The objectives were to determine the incidence of early TE post-pediatric LT and compare differences between children with and without TE. A retrospective review of 88 transplanted children (January 2002-October 2007) was performed to determine the incidence of Doppler-confirmed DVT and ATE in the first month post-LT. Fourteen (16%) patients developed TE: DVT in seven (8%) and ATE in seven (8%) patients. Six of 88 (6.8%) developed symptomatic CVL-related DVT. Median (range) time post-LT to DVT and ATE were 7 (4-18) and 8 (1-31) days, respectively. There was no significant difference in age/body weight at LT between patients with or without DVT and ATE. There was no significant difference between patients with or without HAT in age and weight at LT, cold ischemic time, duration of surgery, hematocrit levels, whole-organ graft type, intraoperative FFP, high-risk CMV status, or early acute cellular rejection. In conclusion, the incidence of early TE post-pediatric LT was 16%, including DVT in 8%. Prospective studies are necessary to evaluate the role of prophylactic anticoagulation and potential modifiable risk factors post-pediatric LT.
    Mesh-Begriff(e) Adolescent ; Anticoagulants/therapeutic use ; Child ; Child, Preschool ; Female ; Humans ; Immunosuppressive Agents/therapeutic use ; Incidence ; Infant ; Liver Transplantation/adverse effects ; Male ; Retrospective Studies ; Risk Factors ; Statistics, Nonparametric ; Thrombosis/diagnostic imaging ; Thrombosis/epidemiology ; Thrombosis/etiology ; Thrombosis/prevention & control ; Ultrasonography, Doppler
    Chemische Substanzen Anticoagulants ; Immunosuppressive Agents
    Sprache Englisch
    Erscheinungsdatum 2010-06
    Erscheinungsland Denmark
    Dokumenttyp Journal Article
    ZDB-ID 1390284-2
    ISSN 1399-3046 ; 1397-3142
    ISSN (online) 1399-3046
    ISSN 1397-3142
    DOI 10.1111/j.1399-3046.2009.01252.x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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