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  1. Article ; Online: Indikation und Ergebnisse der Darmtransplantation bei Kurzdarmsyndrom nach mesenterialer Ischämie.

    Pascher, Andreas

    Chirurgie (Heidelberg, Germany)

    2024  Volume 95, Issue 5, Page(s) 375–381

    Abstract: Background: Intestinal transplantation (ITx) is the only causal treatment for complicated chronic intestinal failure after mesenteric ischemia and impending failure of parenteral supplementation. Isolated or combined ITx with the inclusion of the ... ...

    Title translation Indications and results of intestinal transplantation for short bowel syndrome after mesenteric ischemia.
    Abstract Background: Intestinal transplantation (ITx) is the only causal treatment for complicated chronic intestinal failure after mesenteric ischemia and impending failure of parenteral supplementation. Isolated or combined ITx with the inclusion of the intestine is associated with demanding immunological, perioperative and infection associated challenges.
    Aim: The characterization of chronic intestinal failure, the indications, transplant survival, transplantation techniques and success rates.
    Material and methods: Collection, summary and critical appraisal of international guidelines, the guidelines of the German Medical Chamber, and the international literature.
    Results: The first successful ITx were performed in 1987 and 1988 at the University of Kiel Germany and the University of Pittsburgh, USA. The number of ITx rose continuously but in phases from the end of the 1990s to over 200 per year but has currently decreased to 100-150 per year due to optimized intestinal rehabilitation. While the 1‑year and 3‑year transplant survival rates were 30% and 20% before 1991, they increased in phases up to 60% and 50%, respectively, after 1995 and have now achieved almost 80% and 70%, respectively.
    Conclusion: The substantial improvement in the results of ITx can be partly explained by progress in operative techniques, intensive care medicine and a better understanding of mucosal immunity; however, optimized strategies in immunosuppression as well as prevention of infectious diseases and malignancies have also made decisive contributions.
    MeSH term(s) Humans ; Short Bowel Syndrome/surgery ; Short Bowel Syndrome/complications ; Mesenteric Ischemia/surgery ; Mesenteric Ischemia/complications ; Intestinal Failure ; Intestines/surgery ; Intestinal Diseases/complications ; Intestinal Diseases/surgery ; Chronic Disease
    Language German
    Publishing date 2024-03-01
    Publishing country Germany
    Document type English Abstract ; Journal Article ; Review
    ISSN 2731-698X
    ISSN (online) 2731-698X
    DOI 10.1007/s00104-024-02052-7
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  2. Article ; Online: [No title information]

    Pascher, Andreas

    Zeitschrift fur Gastroenterologie

    2021  Volume 59, Issue 1, Page(s) 23

    Title translation GASL 2021.
    Language German
    Publishing date 2021-01-11
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0172-8504 ; 0044-2771
    ISSN (online) 1439-7803
    ISSN 0172-8504 ; 0044-2771
    DOI 10.1055/a-1331-3966
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  3. Article: GASL 2021

    Pascher, Andreas

    Zeitschrift für Gastroenterologie

    2021  Volume 59, Issue 01, Page(s) 23–23

    Language German
    Publishing date 2021-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/a-1331-3966
    Database Thieme publisher's database

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  4. Article ; Online: Fehler- und Komplikationsmanagement in der Chirurgie.

    Houben, Philipp / Pascher, Andreas

    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen

    2021  Volume 92, Issue 3, Page(s) 232–236

    Abstract: The management of errors and complications makes a significant contribution to the quality assurance of a surgical department. The structured risk management is an integral component of the surgeon's duties that is reflected by the growing relevance of ... ...

    Title translation Management of errors and complications in surgery.
    Abstract The management of errors and complications makes a significant contribution to the quality assurance of a surgical department. The structured risk management is an integral component of the surgeon's duties that is reflected by the growing relevance of simulation and other training methods employed during medical specialist advanced training. Basic prerequisites for establishing an error culture that aims at improvement of patient safety and the constructive coping with complications, are the removal of taboos and the transparent processing of complicating courses of treatment. Detecting structural and systemic sources of error is preferrable to the application of approaches that focus on individual responsibility, e.g. shame and blame. There are numerous validated tools available for the prevention, recognition and successful treatment of complications. Team time out protocols for circumventing fatal errors, standardized operating procedures and morbidity and mortality conferences are the most important measures for ensuring patient safety. The standardized, consistent and interdisciplinary handling of unavoidable complications according to the failure to rescue concept is pivotal for the prevention of a fatal course.
    MeSH term(s) Humans ; Medical Errors/prevention & control ; Patient Safety ; Risk Management
    Language German
    Publishing date 2021-01-11
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1521-0
    ISSN 1433-0385 ; 0009-4722
    ISSN (online) 1433-0385
    ISSN 0009-4722
    DOI 10.1007/s00104-020-01336-y
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  5. Article ; Online: Targeting Ischemia Reperfusion in Intestinal Transplantation by COX-2 Inhibition-A S.M.A.R.T Approach?

    Pascher, Andreas

    Transplantation

    2016  Volume 100, Issue 11, Page(s) 2244–2245

    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208424-7
    ISSN 1534-6080 ; 0041-1337
    ISSN (online) 1534-6080
    ISSN 0041-1337
    DOI 10.1097/TP.0000000000001318
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  6. Article ; Online: Editorial introduction.

    Pascher, Andreas

    Current opinion in organ transplantation

    2016  Volume 21, Issue 2, Page(s) 133–134

    Language English
    Publishing date 2016-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 1390429-2
    ISSN 1531-7013 ; 1087-2418
    ISSN (online) 1531-7013
    ISSN 1087-2418
    DOI 10.1097/MOT.0000000000000291
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    Zs.A 5609: Show issues Location:
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  7. Article ; Online: The role of cytoreductive surgery and HIPEC for the treatment of primary and secondary peritoneal malignancies-experience from a tertiary care center in Germany.

    Reese, Mikko / Eichelmann, Ann-Kathrin / Nowacki, Tobias M / Pascher, Andreas / Sporn, Judith C

    Langenbeck's archives of surgery

    2024  Volume 409, Issue 1, Page(s) 113

    Abstract: Purpose: Peritoneal surface malignancies (PSM) are commonly known to have a dismal prognosis. Over the past decades, novel techniques such as cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), and pressurized intraperitoneal ...

    Abstract Purpose: Peritoneal surface malignancies (PSM) are commonly known to have a dismal prognosis. Over the past decades, novel techniques such as cytoreductive surgery (CRS), hyperthermic intraperitoneal chemotherapy (HIPEC), and pressurized intraperitoneal aerosol chemotherapy (PIPAC) have been introduced for the treatment of PSM which could improve the overall survival and quality of life of patients with PSM. The decision to proceed with CRS and HIPEC is often challenging due the complexity of the disease, the extent of the procedure, associated side effects, and potential risks. Here, we present our experience with CRS and HIPEC to add to the ongoing discussion about eligibility criteria, technical approach, and expected outcomes and contribute to the evolution of this powerful and promising tool in the multidisciplinary treatment of patients with primary and secondary PSM.
    Methods: A single-center retrospective chart review was conducted and included a total of 40 patients treated with CRS and HIPEC from April 2020 to September 2022 at the University Hospital Münster Department of Surgery. All patients had histologically confirmed primary or secondary peritoneal malignancies of various primary origins.
    Results: Our study included 22 patients with peritoneal metastases from gastric cancer (55%), 8 with pseudomyxoma peritonei (20%), 4 with mesothelioma of the peritoneum (10%), and 6 patients with PSM originating from other primary tumor locations. Median PCI at time of cytoreduction was 4 (0-25). Completeness of cytoreduction score was 0 in 37 patients (92.5%), 1 in two patients (5%), and 2 in one patient (2.5%). Median overall survival across all patients was 3.69 years.
    Conclusion: Complete cytoreduction during CRS and HIPEC can be achieved for patients with low PCI, for patients with high PCI in low-grade malignancies, and even for patients with initially high PCI in high-grade malignancies following a significant reduction of cancer burden due to extensive preoperative treatment with PIPAC and systemic chemotherapy.
    MeSH term(s) Humans ; Peritoneal Neoplasms/pathology ; Peritoneum ; Hyperthermic Intraperitoneal Chemotherapy ; Cytoreduction Surgical Procedures ; Retrospective Studies ; Tertiary Care Centers ; Percutaneous Coronary Intervention ; Quality of Life ; Hyperthermia, Induced ; Combined Modality Therapy ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Survival Rate
    Language English
    Publishing date 2024-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-024-03309-9
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  8. Article: Innate Immune Cells during Machine Perfusion of Liver Grafts-The Janus Face of Hepatic Macrophages.

    Roushansarai, Nicola Sariye / Pascher, Andreas / Becker, Felix

    Journal of clinical medicine

    2022  Volume 11, Issue 22

    Abstract: Machine perfusion is an emerging technology in the field of liver transplantation. While machine perfusion has now been implemented in clinical routine throughout transplant centers around the world, a debate has arisen regarding its concurrent effect on ...

    Abstract Machine perfusion is an emerging technology in the field of liver transplantation. While machine perfusion has now been implemented in clinical routine throughout transplant centers around the world, a debate has arisen regarding its concurrent effect on the complex hepatic immune system during perfusion. Currently, our understanding of the perfusion-elicited processes involving innate immune cells remains incomplete. Hepatic macrophages (Kupffer cells) represent a special subset of hepatic immune cells with a dual pro-inflammatory, as well as a pro-resolving and anti-inflammatory, role in the sequence of ischemia-reperfusion injury. The purpose of this review is to provide an overview of the current data regarding the immunomodulatory role of machine perfusion and to emphasize the importance of macrophages for hepatic ischemia-reperfusion injury.
    Language English
    Publishing date 2022-11-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11226669
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  9. Article ; Online: The charm of "small data".

    Pascher, Andreas

    Transplant international : official journal of the European Society for Organ Transplantation

    2015  Volume 28, Issue 12, Page(s) 1357–1358

    MeSH term(s) Heart Failure ; Humans
    Language English
    Publishing date 2015-12
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 639435-8
    ISSN 1432-2277 ; 0934-0874
    ISSN (online) 1432-2277
    ISSN 0934-0874
    DOI 10.1111/tri.12655
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  10. Article: Quantification of Indocyanine Green Fluorescence Imaging in General, Visceral and Transplant Surgery.

    Pollmann, Lukas / Juratli, Mazen / Roushansarai, Nicola / Pascher, Andreas / Hölzen, Jens Peter

    Journal of clinical medicine

    2023  Volume 12, Issue 10

    Abstract: Near-infrared (NIR) imaging with indocyanine green (ICG) has proven to be useful in general, visceral, and transplant surgery. However, most studies have performed only qualitative assessments. Therefore, a systematic overview of all studies performing ... ...

    Abstract Near-infrared (NIR) imaging with indocyanine green (ICG) has proven to be useful in general, visceral, and transplant surgery. However, most studies have performed only qualitative assessments. Therefore, a systematic overview of all studies performing quantitative indocyanine green evaluation in general, visceral, and transplant surgeries should be conducted. Free term and medical subject heading (MeSH) term searches were performed in the Medline and Cochrane databases until October 2022. The main categories of ICG quantification were esophageal surgery (24.6%), reconstructive surgery (24.6%), and colorectal surgery (21.3%). Concordantly, anastomotic leak (41%) was the main endpoint, followed by the assessment of flap perfusion (23%) and the identification of structures and organs (14.8%). Most studies examined open surgery (67.6%) or laparoscopic surgery (23.1%). The analysis was mainly carried out using manufacturer software (44.3%) and open-source software (15.6%). The most frequently analyzed parameter was intensity over time for blood flow assessment, followed by intensity alone or intensity-to-background ratios for structure and organ identification. Intraoperative ICG quantification could become more important with the increasing impact of robotic surgery and machine learning algorithms for image and video analysis.
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12103550
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