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  1. Article: Is the Whole More Than the Sum of Its Parts? Health Effects of Different Types of Traffic Noise Combined

    Seidler, Andreas / Seidler, Anna Lene / Schubert, Melanie / Zeeb, Hajo

    International journal of environmental research and public health, 16(9):1665

    2019  

    Abstract: Many epidemiological studies find that people exposed to aircraft, road or railway traffic noise are at increased risk of illness, including cardiovascular disease (CVD) and depression. It is unclear how the combined exposure to these different types of ... ...

    Institution Leibniz-Institut für Präventionsforschung und Epidemiologie
    Abstract Many epidemiological studies find that people exposed to aircraft, road or railway traffic noise are at increased risk of illness, including cardiovascular disease (CVD) and depression. It is unclear how the combined exposure to these different types of traffic noise affects disease risks. This study addresses this question with a large secondary data-based case-control study (“NORAH disease risk study”). The Akaike information criterion (AIC) is used to compare two different models estimating the disease risks of combined traffic noise. In comparison with the conventional energetic addition of noise levels, the multiplication of CVD risks as well as depression risks reveals a considerably better model fit as expressed by much lower AIC values. This is also the case when risk differences between different types of traffic noise are taken into account by applying supplements or reductions to the single traffic noise pressure levels in order to identify the best fitting energetic addition model. As a consequence, the conventionally performed energetic addition of noise levels might considerably underestimate the health risks of combined traffic noise. Based on the NORAH disease risk study, “epidemiological risk multiplication” seems to provide a better estimate of the health risks of combined traffic noise exposures compared to energetic addition. If confirmed in further studies, these results should imply consequences for noise protection measures as well as for traffic planning.
    Keywords Disease risks ; Energetic noise addition ; Epidemiological risk multiplication ; Traffic noise
    Language English
    Document type Article
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  2. Article: Behavioral and Emotional Disorders and Transportation Noise among Children and Adolescents: A Systematic Review and Meta-Analysis

    Schubert, Melanie / Romero Starke, Karla / Zeeb, Hajo / Seidler, Andreas

    International journal of environmental research and public health, 16(18):3336

    2019  

    Abstract: Children and adolescents may be particularly vulnerable to environmental influences such as noise which can affect mental well-being. The aim of this systematic review was to evaluate the effect of transportation noise on behavioral and emotional ... ...

    Institution Leibniz-Institut für Präventionsforschung und Epidemiologie
    Abstract Children and adolescents may be particularly vulnerable to environmental influences such as noise which can affect mental well-being. The aim of this systematic review was to evaluate the effect of transportation noise on behavioral and emotional disorders in children and adolescents using a meta-analytic approach. Therefore, we searched four databases (Pubmed, Embase, PsychINFO, and PSYNDEX) and grey literature until February of 2019. We identified 14 articles from 10 studies examining the effect of transportation noise exposure on the mental health of children. These studies predominately used the Strength and Difficulties Questionnaire (SDQ) and mainly focused on schoolchildren and adolescents aged 9–10 years and 15–17 years in Europe. Three studies could be included in the meta-analysis. In sum, the odds for hyperactivity/inattention and total difficulties was significantly increased by 11% (Odds Ratio, OR = 1.11 (95% Confidence Interval, CI 1.04–1.19), respectively 9% (95% CI 1.02–1.16) per 10 dB road traffic noise. Thus, we obtained evidence for an effect of road traffic noise on hyperactivity/inattention and total difficulties, although we could consider few studies. Future studies are needed that use similar techniques to assess outcomes and exposures at schools and in homes. This would make it possible to conduct an individual participant data pooled analysis of the data.
    Keywords Cognition disorders ; Anxiety ; Aircraft noise ; Depression ; Disruptive behavior disorders ; Noise ; Noise pollution ; Psychology ; Road traffic noise ; Railway noise ; Traffic noise ; Transportation
    Language English
    Document type Article
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  3. Article ; Online: Fertility Preservation in Endometrial Cancer-Treatment and Molecular Aspects.

    Schubert, Melanie / Mettler, Liselotte / Deenadayal Tolani, Aarti / Alkatout, Ibrahim

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 2

    Abstract: Endometrial cancer is one of the most common gynecological malignancies worldwide; incidences are rising, with 417,367 new cases registered in 2020. Of these, the proportion of women that are of reproductive age is around 4-14% and the number is ... ...

    Abstract Endometrial cancer is one of the most common gynecological malignancies worldwide; incidences are rising, with 417,367 new cases registered in 2020. Of these, the proportion of women that are of reproductive age is around 4-14% and the number is increasing. Thus, in addition to oncological therapy and safety, the preservation of fertility plays a central role in therapeutic strategies. Molecular genetic patient data provide a robust supplementary benefit that improves primary risk assessment and can help design personalized treatment options to curtail over- and undertreatment and contribute to fertility preserving strategies. The aim of our review is to provide an overview of the latest significant recommendations in the diagnosis and therapy of endometrial cancer during reproductive age. In this paper the most recent groundbreaking molecular discoveries in endometrial cancer are highlighted and discussed as an opportunity to enhance the prognostic and therapy options in this special patient collective.
    MeSH term(s) Female ; Humans ; Fertility Preservation ; Endometrial Neoplasms/pathology ; Reproductive Techniques, Assisted ; Prognosis ; Genital Neoplasms, Female
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59020221
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Patients risk for mortality at 90 days after proximal femur fracture - a retrospective study in a tertiary care hospital.

    Postler, Anne / Posten, Charlotte / Schubert, Melanie / Beyer, Franziska / Lützner, Jörg / Vicent, Oliver / Kleber, Christian / Goronzy, Jens / Kamin, Konrad

    BMC geriatrics

    2024  Volume 24, Issue 1, Page(s) 130

    Abstract: Background: Despite improving the management of proximal femur fractures (PFF) with legal requirements of timing the surgery within 24 h, mortality rates in these patients remain still high. The objective of our study was to analyze potential cofactors ... ...

    Abstract Background: Despite improving the management of proximal femur fractures (PFF) with legal requirements of timing the surgery within 24 h, mortality rates in these patients remain still high. The objective of our study was to analyze potential cofactors which might influence the mortality rate within 90 days after surgery in PFF to avoid adverse events, loss of quality of life and high rates of mortality.
    Methods: In this retrospective, single-center study all patients with PFF aged 65 years and older were included. We recorded gender, age, type of fracture, surgery and anesthesia, time, comorbidities and medication as well as complications and mortality rate at 90 days. Separate logistic regression models were used to assess which parameters were associated with patients' mortality. The mortality rate was neither associated with timing, time and type of surgery nor time and type of anesthesia, but with higher age (OR 1.08 per year; 95% CI 1.034-1.128), lower BMI (OR 0.915 per kg/m
    Results: We analyzed a total of 734 patients (age ≥ 65 years) who had a PFF in 2019 and 2020 and received surgery. 129 patients (17.6%) died until 90 days at an median age of 89.7 years (range 65-101 years).
    Conclusion: The proportion of patients who died until 90 days after surgery is still high. It is less extend influenced by surgical and anaesthesiologic factors than by patient-related factors like age or lower BMI. Physicians should be aware of the importance of avoiding adverse events and the importance of patients' mobilization to reduce mortality and improve patients' outcome.
    MeSH term(s) Humans ; Aged ; Aged, 80 and over ; Retrospective Studies ; Hip Fractures/surgery ; Proximal Femoral Fractures ; Quality of Life ; Tertiary Care Centers ; Risk Factors
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2059865-8
    ISSN 1471-2318 ; 1471-2318
    ISSN (online) 1471-2318
    ISSN 1471-2318
    DOI 10.1186/s12877-024-04733-8
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  5. Article ; Online: Corrigendum to "Health effects of railway-induced vibration combined with railway noise - A systematic review with exposure-effect curves" [Environ. Res. 233 (2023) 116480].

    Seidler, Andreas / Schubert, Melanie / Mehrjerdian, Yasmin / Krapf, Klaus / Popp, Christian / van Kamp, Irene / Ögren, Mikael / Hegewald, Janice

    Environmental research

    2024  Volume 251, Issue Pt 1, Page(s) 118658

    Language English
    Publishing date 2024-03-12
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118658
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  6. Article ; Online: The Burden of Disease Due to Road Traffic Noise in Hesse, Germany.

    Hegewald, Janice / Schubert, Melanie / Lochmann, Matthias / Seidler, Andreas

    International journal of environmental research and public health

    2021  Volume 18, Issue 17

    Abstract: Road-traffic-noise exposition is widespread in Germany and can have harmful health effects. As guidance for informed decision-making, we estimated the environmental burden of disease attributable to road-traffic noise in Hesse, Germany as disability- ... ...

    Abstract Road-traffic-noise exposition is widespread in Germany and can have harmful health effects. As guidance for informed decision-making, we estimated the environmental burden of disease attributable to road-traffic noise in Hesse, Germany as disability-adjusted life-years (DALYs). Using detailed road-traffic-noise exposure data provided by the Hessian Agency for Nature Conservation, Environment, and Geology (HLNUG), we calculated the DALYs due to road-traffic noise > 40 dB(A) L
    MeSH term(s) Cost of Illness ; Environmental Exposure/adverse effects ; Germany/epidemiology ; Humans ; Noise, Transportation/adverse effects ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/etiology
    Language English
    Publishing date 2021-09-03
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph18179337
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  7. Article ; Online: Challenges in the Diagnosis and Individualized Treatment of Cervical Cancer.

    Schubert, Melanie / Bauerschlag, Dirk Olaf / Muallem, Mustafa Zelal / Maass, Nicolai / Alkatout, Ibrahim

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 5

    Abstract: Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic ... ...

    Abstract Cervical cancer is still the fourth most common cancer in women throughout the world; an estimated 604,000 new cases were observed in 2020. Better knowledge of its pathogenesis, gained in recent years, has introduced new preventive and diagnostic approaches. Knowledge of its pathogenesis has made it possible to provide individualized surgical and drug treatment. In industrialized countries, cervical cancer has become a less frequent tumor entity due to the accessibility of the human papilloma virus vaccination, systematic preventive programs/early detection programs, health care infrastructure and the availability of effective therapy options. Nevertheless, globally, neither mortality nor morbidity has been significantly reduced over the past 10 years, and therapy approaches differ widely. The aim of this review is to address recent advances in the prevention, diagnostic investigation and treatment of cervical cancer globally, focusing on advances in Germany, with a view toward providing an updated overview for clinicians. The following aspects are addressed in detail: (a) the prevalence and causes of cervical cancer, (b) diagnostic tools using imaging techniques, cytology and pathology, (c) pathomechanisms and clinical symptoms of cervical cancer and (d) different treatment approaches (pharmacological, surgical and others) and their impact on outcomes.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/therapy ; Uterine Cervical Neoplasms/prevention & control ; Immunization ; Developed Countries ; Prevalence ; Early Detection of Cancer ; Papillomavirus Infections/prevention & control
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59050925
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  8. Article ; Conference proceedings: Recommendations for Data Extraction in Occupational Epidemiological Systematic Reviews

    Schubert, Melanie / Smolinska, Joanna / Drossard, Claudia / Hegewald, Janice / Seidler, Andreas

    Das Gesundheitswesen

    2023  Volume 85, Issue 08/09

    Event/congress Gemeinsame Jahrestagung der Deutschen Gesellschaft für Sozialmedizin und Prävention e.V. (DGSMP)*, des Deutschen Netzwerks Gesundheitskompetenz e. V. (DNGK) und des Nationalen Aktionsplans Gesundheitskompetenz (NAP), Hannover, 2023-08-30
    Language German
    Publishing date 2023-08-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
    DOI 10.1055/s-0043-1770562
    Database Thieme publisher's database

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  9. Book ; Online ; Thesis: Auswirkungen der radikal operativen Therapie des Vulvakarzinoms auf die Lebensqualität

    Schubert, Melanie [Verfasser]

    2016  

    Author's details Melanie Schubert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Kiel
    Publishing place Kiel
    Document type Book ; Online ; Thesis
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  10. Article ; Online: Health effects of railway-induced vibration combined with railway noise - A systematic review with exposure-effect curves.

    Seidler, Andreas / Schubert, Melanie / Mehrjerdian, Yasmin / Krapf, Klaus / Popp, Christian / van Kamp, Irene / Ögren, Mikael / Hegewald, Janice

    Environmental research

    2023  Volume 233, Page(s) 116480

    Abstract: Background: The combined health impact of concurrent railway noise and railway vibration exposure is not yet well understood.: Objectives: This systematic review gives an overview of epidemiological studies on health effects from railway vibration, ... ...

    Abstract Background: The combined health impact of concurrent railway noise and railway vibration exposure is not yet well understood.
    Objectives: This systematic review gives an overview of epidemiological studies on health effects from railway vibration, aiming to quantify this association with exposure-effect curves. Moreover, the combined health effects of vibration and concurrent noise were investigated.
    Methods: We converted the vibration metric to an equivalent noise level and calculated an overall noise level by energetically summing the equivalent and railway noise level. The combined health effect was determined by using published evidence-based exposure-effect formulas.
    Results: Studies included in this systematic review predominately investigated annoyance and self-reported sleep disturbances; no studies on manifest diseases were identified. For the combined effects of vibration and noise on "total" annoyance, the results based on the pooled analysis of CargoVibes project are recommended as conservative approach.
    Discussion: Converting railway vibration into equivalent noise levels in dB may offer a pragmatic approach to assess the combined health effects of railway noise and railway vibration exposure. Future studies should include cardiovascular and mental diseases in addition to vibration-induced annoyance and sleep disturbances. Furthermore, future studies should include in-depth investigations of the interaction between railway noise and railway vibration to allow for a more accurate assessment of the railway-induced burden of disease.
    MeSH term(s) Humans ; Vibration/adverse effects ; Noise, Transportation/adverse effects ; Heart ; Mental Disorders ; Self Report ; Railroads ; Environmental Exposure/adverse effects
    Language English
    Publishing date 2023-06-21
    Publishing country Netherlands
    Document type Systematic Review ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2023.116480
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