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  1. Article ; Online: Guidelines on percutaneous nephrolithotomy.

    Seitz, Christian

    Minerva urology and nephrology

    2022  Volume 74, Issue 6, Page(s) 789–790

    MeSH term(s) Humans ; Nephrolithotomy, Percutaneous ; Nephrostomy, Percutaneous ; Kidney Calculi/surgery
    Language English
    Publishing date 2022-10-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 3062840-4
    ISSN 2724-6442
    ISSN (online) 2724-6442
    DOI 10.23736/S2724-6051.22.05126-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 16: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  2. Book ; Online ; Thesis: Klinische Untersuchung der Wirksamkeit zweier Liganden am Progesteronrezeptor zur Behandlung gynäkologischer Erkrankungen

    Seitz, Christian [Verfasser]

    2022  

    Author's details Christian Seitz
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Medizinische Fakultät Charité - Universitätsmedizin Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  3. Book ; Thesis: Charakterisierung dreier monoklonaler Antikörper gegen HLA-B27/Peptid-Komplexe

    Seitz, Christian

    2004  

    Author's details von Christian Seitz
    Language German
    Size 89 Bl. : graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Freie Univ., Diss., 2004
    HBZ-ID HT014228026
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2003 MB 653 order for loan Magazin

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  4. Article ; Online: Re: Do JJ Stents Increase the Effectiveness of Extracorporeal Shock Wave Lithotripsy for Pediatric Renal Stones?

    Seitz, Christian

    Urologia internationalis

    2018  Volume 100, Issue 3, Page(s) 353–354

    MeSH term(s) Child ; Humans ; Kidney Calculi ; Lithotripsy ; Stents
    Language English
    Publishing date 2018
    Publishing country Switzerland
    Document type Editorial ; Comment
    ZDB-ID 204045-1
    ISSN 1423-0399 ; 0042-1138
    ISSN (online) 1423-0399
    ISSN 0042-1138
    DOI 10.1159/000487197
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    Ui VI Zs.180: Show issues Location:
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  5. Article ; Online: Re: Zhangqun Ye, Guohua Zeng, Huan Yang, et al. Efficacy and Safety of Tamsulosin in Medical Expulsive Therapy for Distal Ureteral Stones with Renal Colic: A Multicenter, Randomized, Double-blind, Placebo-controlled Trial. Eur Urol 2018;73:385-91.

    Seitz, Christian

    European urology

    2018  Volume 73, Issue 4, Page(s) e91

    MeSH term(s) Double-Blind Method ; Humans ; Renal Colic ; Sulfonamides ; Tamsulosin ; Ureteral Calculi
    Chemical Substances Sulfonamides ; Tamsulosin (G3P28OML5I)
    Language English
    Publishing date 2018-01-11
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2017.12.032
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    Zs.A 1247: Show issues Location:
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    Zs.MO 294: Show issues

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  6. Article ; Online: Re: Removal of Small, Asymptomatic Kidney Stones and Incidence of Relapse.

    Seitz, Christian / Kikic, Zejlko

    European urology

    2022  Volume 83, Issue 1, Page(s) 93

    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.10.003
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    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  7. Article ; Online: Editorial: Future of kidney stone management.

    Somani, Bhaskar / Seitz, Christian

    Current opinion in urology

    2022  Volume 33, Issue 2, Page(s) 71–72

    MeSH term(s) Humans ; Kidney Calculi/therapy
    Language English
    Publishing date 2022-10-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 1091792-5
    ISSN 1473-6586 ; 0963-0643
    ISSN (online) 1473-6586
    ISSN 0963-0643
    DOI 10.1097/MOU.0000000000001067
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    Zs.A 3345: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  8. Article ; Online: Glycosylation and Crowded Membrane Effects on Influenza Neuraminidase Stability and Dynamics.

    Seitz, Christian / Deveci, İlker / McCammon, J Andrew

    The journal of physical chemistry letters

    2023  Volume 14, Issue 44, Page(s) 9926–9934

    Abstract: All protein simulations are conducted with varying degrees of simplification, oftentimes with unknown ramifications about how these simplifications affect the interpretability of the results. In this work, we investigated how protein glycosylation and ... ...

    Abstract All protein simulations are conducted with varying degrees of simplification, oftentimes with unknown ramifications about how these simplifications affect the interpretability of the results. In this work, we investigated how protein glycosylation and lateral crowding effects modulate an array of properties characterizing the stability and dynamics of influenza neuraminidase. We constructed three systems: (1) glycosylated neuraminidase in a whole virion (i.e., crowded membrane) environment, (2) glycosylated neuraminidase in its own lipid bilayer, and (3) unglycosylated neuraminidase in its own lipid bilayer. We saw that glycans tend to stabilize the protein structure and reduce its conformational flexibility while restricting the solvent movement. Conversely, a crowded membrane environment encouraged exploration of the free energy landscape and a large-scale conformational change, while making the protein structure more compact. Understanding these effects informs what factors one must consider in attempting to recapture the desired level of physical accuracy.
    MeSH term(s) Humans ; Influenza, Human ; Neuraminidase/chemistry ; Neuraminidase/metabolism ; Glycosylation ; Lipid Bilayers ; Viral Proteins/chemistry
    Chemical Substances Neuraminidase (EC 3.2.1.18) ; Lipid Bilayers ; Viral Proteins
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7185
    ISSN (online) 1948-7185
    DOI 10.1021/acs.jpclett.3c02524
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  9. Article ; Online: Substituting a randomised placebo control group with a historical placebo control in an endometriosis pain trial: a case study re-evaluating trial data using historical control data from another trial.

    Sieverding, Marius / Gerlinger, Christoph / Seitz, Christian

    BMJ open

    2023  Volume 13, Issue 7, Page(s) e063188

    Abstract: Objective: The substitution of an in-study control population with a historical control (HC) population is considered a viable option for reducing the necessary recruitment of control patients. However, it is necessary to evaluate whether this method is ...

    Abstract Objective: The substitution of an in-study control population with a historical control (HC) population is considered a viable option for reducing the necessary recruitment of control patients. However, it is necessary to evaluate whether this method is applicable to studies on indications targeting endometriosis-associated pelvic pain (EAPP). This study aims to evaluate the potential bias in the results of an EAPP study with an HC arm.
    Methods: For this case study, we re-evaluated data from a randomised, placebo-controlled trial using dienogest daily to treat EAPP with an HC arm based on data from a second randomised, placebo-controlled trial in the same indication. Propensity Score (PS) matching was used to match between the treatment and HC arm on all baseline variables. To evaluate the effect of matching on the introduced bias, we evaluated efficacy parameters with the full treatment and control group, as well as the matched group.
    Results: The difference between means (placebo minus treatment) in change in pain, as measured on the Visual Analogue Scale from baseline to end of treatment, deviates in the comparison treatment/pool of HC (7.15 (0.22 to 14.08)) from the overall in-study group (reference: 11.89 (6.06 to 17.73)). After PS matching on the baseline variables, the difference between means (11.79 (4.09 to 19.5)) is close to the reference.
    Conclusions: Using HC with PS matching has proven to be useful in the setting of treating EAPP, while emphasis must be given to the selection mechanism and the underlying assumptions. This case study has shown that even for studies which are very similar in design, heterogeneity and between-study variations are present. With the use of an HC arm, it was possible to reproduce similar results than in the original study, while the PS matching improved the comparability considerably. For the main endpoint, PS matching could reproduce the original study results.
    Trial registration number: NCT00225199, NCT00185341.
    MeSH term(s) Female ; Humans ; Endometriosis/complications ; Endometriosis/drug therapy ; Control Groups ; Pelvic Pain/drug therapy ; Pelvic Pain/etiology ; Pain Measurement ; Propensity Score
    Language English
    Publishing date 2023-07-21
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2599832-8
    ISSN 2044-6055 ; 2044-6055
    ISSN (online) 2044-6055
    ISSN 2044-6055
    DOI 10.1136/bmjopen-2022-063188
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  10. Article: Glycosylation and Crowded Membrane Effects on Influenza Neuraminidase Stability and Dynamics.

    Seitz, Christian / Deveci, İlker / McCammon, J Andrew

    bioRxiv : the preprint server for biology

    2023  

    Abstract: All protein simulations are conducted with varying degrees of simplifications, oftentimes with unknown ramifications on how these simplifications affect the interpretability of the results. In this work we investigated how protein glycosylation and ... ...

    Abstract All protein simulations are conducted with varying degrees of simplifications, oftentimes with unknown ramifications on how these simplifications affect the interpretability of the results. In this work we investigated how protein glycosylation and lateral crowding effects modulate an array of properties characterizing the stability and dynamics of influenza neuraminidase. We constructed three systems: 1) Glycosylated neuraminidase in a whole virion (i.e. crowded membrane) environment 2) Glycosylated neuraminidase in its own lipid bilayer 3) Unglycosylated neuraminidase in its own lipid bilayer. We saw that glycans tend to stabilize the protein structure and reduce its conformational flexibility while restricting solvent movement. Conversely, a crowded membrane environment encouraged exploration of the free energy landscape and a large scale conformational change while making the protein structure more compact. Understanding these effects informs what factors one must consider while attempting to recapture the desired level of physical accuracy.
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.09.10.556910
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